metabolic⚑ High burden in India

Insulin resistance

resistance (IR) is a pathological response in which cells in insulin-sensitive in the body fail to respond normally to the insulin or downregulate insulin receptors in response to hyperinsulinemia.

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Causes — why it happens

·Lipotoxicity, use of glucocorticoids, anti-adrenergic, protease , selective serotonin reuptake inhibitors, atypical antipsychotics.

How it's found

·Glucose challenge test, Glucose clamp technique.

Complications

·Nonalcoholic fatty liver disease, disease.

Outlook

·Hyperglycemia, , dyslipidemia, hyperuricemia, elevated markers, endothelial , a prothrombotic state, and polycystic ovary (PCOS).

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Plain-language summary adapted from Wikipedia. Not medical advice.