D2I2.
endocrine

Cushing's syndrome

Cushing's is a collection of signs and symptoms due to prolonged exposure to glucocorticoids such as cortisol. Signs and symptoms may include high blood pressure, but with thin arms and legs, reddish stretch marks, a round red face due to facial plethora, a fat lump between the shoulders, weak muscles, weak bones, acne, and fragile skin that heals poorly. Women may have more hair and irregular menstruation or loss of menses, the exact mechanism of which are unknown. Occasionally there may be changes in mood, headaches, and a feeling of tiredness.

Underlined words are explained — tap any of them.

Symptoms — what it feels like

  • ·High blood pressure, with thin arms and legs, reddish stretch marks, round face, often reddened due to facial plethora, fat lump between the shoulders, weak muscles, acne, fragile skin

Causes — why it happens

  • ·Prolonged exposure to cortisol

How it's found

  • ·Requires a number of steps

Treatment

  • ·Based on underlying cause

Complications

  • ·High blood pressure (), Type 2 , Frequent or unusual , Loss of muscle mass and strength, Bone loss (osteoporosis).

Outlook

  • ·Generally good with treatment
Plain-language summary adapted from Wikipedia. Not medical advice.