MODY (mature-onset diabetes of the young)
Maturity-onset of the young (MODY) refers to any of several forms of diabetes caused by in an gene disrupting production. Along with diabetes, MODY is a form of the conditions known as diabetes. While the more common types of diabetes involve more complex combinations of causes involving multiple genes and environmental factors, each form of MODY is caused by changes to a single gene (monogenic). HNF1A-MODY are the most common forms.
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Across the (mody) gene set (GCK, HNF1A, HNF4A), 38 -'' are actually seen in South Asians () - many European-absent and still clinically 'uncertain'. For mody (mature-onset diabetes of the young), that's a pool of computationally-damaging, India-relevant, clinically-unresolved variants no one has systematically characterised.
A study that would help: Take the South-Asian-observed, European-absent, ClinVar-uncertain in GCK, HNF1A, HNF4A and triage them for mody (mature-onset of the young): functional assays or family segregation to move them from 'uncertain' to a real call. Each reclassified is a usable diagnostic result.