D2I2.
congenital

Lissencephaly

Lissencephaly is a set of rare brain disorders whereby the whole or parts of the surface of the brain are smooth. It is caused by defective neuronal migration during the 12th to 24th weeks of gestation, resulting in a lack of development of brain folds (gyri) and grooves (sulci). It is a form of cephalic disorder. Terms such as agyria and pachygyria are used to describe the appearance of the surface of the brain.

Underlined words are explained — tap any of them.

Causes — why it happens

  • ·Absence of gyrification

Treatment

  • ·See below

Outlook

  • ·Usually die young; see below for details
Plain-language summary adapted from Wikipedia. Not medical advice.