Dyslipidaemia (high cholesterol)
Dyslipidemia is a disorder characterized by abnormally high or low amounts of any or all lipids or lipoproteins in the blood. Dyslipidemia is a risk factor for the development of atherosclerotic diseases, which include disease, cerebrovascular disease, and artery disease. Although dyslipidemia is a risk factor for cardiovascular disease, abnormal levels do not mean that lipid lowering agents need to be started. Other factors, such as comorbid conditions and lifestyle in addition to dyslipidemia, is considered in a cardiovascular risk assessment. In developed countries, most dyslipidemias are hyperlipidemias; that is, an elevation of lipids in the blood. This is often due to diet and lifestyle. Prolonged elevation of resistance can also lead to dyslipidemia.
Underlined words are explained — tap any of them.
Symptoms — what it feels like
- ·Atherosclerosis
Complications
- · disease, disease
A European-trained for dyslipidaemia (high ) flags 16.4% of Gujarati people as high-risk - vs the 10% it was designed for. That's a 1.6x mis-stratification: the score's 'average' is set to European , so it systematically mis-reads South Asians (a +0.40 SD mean shift).
A study that would help: Recalibrate PGS000061 on an Indian (define the threshold on South-Asian, not European, risk) and quantify how many people get correctly re-classified. A concrete, fundable validation study once a genotyped+phenotyped Indian sample is in hand.