X-linked agammaglobulinemia

X-linked agammaglobulinemia (XLA) is a rare genetic disorder that affects the body's ability to fight infection due to the inability to create mature B cells, which produce antibodies. First described in 1952, it is a primary immunodeficiency caused by a mutation on X chromosome (Xq21.3-q22), making it X-linked and therefore much more common in males.

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