Myelofibrosis
Primary myelofibrosis (PMF) is a rare bone blood cancer. It is classified by the World Health Organization (WHO) as a type of myeloproliferative , a group of cancers in which there is activation and growth of mutated cells in the bone marrow. This is most often associated with a somatic in the JAK2, CALR, or MPL genes. In PMF, the bony aspects of bone marrow are remodeled in a process called osteosclerosis; in addition, fibroblasts secrete collagen and reticulin proteins that are collectively referred to as . These two pathological processes compromise the normal function of bone marrow, resulting in decreased production of blood cells such as erythrocytes, granulocytes, and megakaryocytes. The latter are responsible for the production of .
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