Locked-in syndrome

Locked-in syndrome (LIS), also known as pseudocoma, is a condition in which a patient is aware but cannot move or communicate verbally due to complete paralysis of nearly all voluntary muscles in their body except for vertical eye movements and blinking. This is due to quadriplegia and bulbar palsy. The person is conscious and sufficiently intact cognitively to communicate with eye movements. Electroencephalography results are normal in locked-in syndrome as these people have retained brain activity such as sleep-wake cycles and attention that is detectable. Fred Plum and Jerome B. Posner coined the term in 1966.

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