D2I2.
genetic

Klinefelter syndrome

Klinefelter (KS), also known as 47,XXY, is a anomaly. Subjects affected by the condition are almost always phenotypically male, with common such as and small, poorly functioning testicles. These symptoms are often noticed only at puberty, although this is one of the most common chromosomal disorders. The birth of KS in the State of Victoria, Australia, was estimated to be 223 per 100,000 males. It is named after American endocrinologist Harry Klinefelter, who identified the condition in the 1940s, along with his colleagues at Massachusetts General Hospital.

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Symptoms — what it feels like

  • ·Varied; include above average height, weaker muscles, poor coordination, less body hair, breast growth, small testicle size, sexual ,

Causes — why it happens

  • ·Nondisjunction during gametogenesis or in a zygote

How it's found

  • · testing (karyotype)

Prevention

  • ·None

Treatment

  • ·Physical therapy, speech and language therapy, Testosterone Supplementation, counseling

Complications

  • ·, intellectual disability, disorders, breast cancer, thromboembolic disease, osteoporosis

Outlook

  • ·Nearly normal life expectancy
Plain-language summary adapted from Wikipedia. Not medical advice.