D2I2.
autoimmune

Cryoglobulinaemia

Cryoglobulinemia is a rare medical condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins composed of immunoglobulins and sometimes complement components. Cryoglobulins specifically form gel-like solids by clumping together and becoming insoluble at temperatures below 37 °C.

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Plain-language summary adapted from Wikipedia. Not medical advice.