genetic

Common variable immunodeficiency

Common variable (CVID) is an inborn disorder characterized by recurrent and low antibody levels, specifically in (Ig) types IgG, IgM, and IgA. Symptoms generally include high susceptibility to pathogens, lung disease, as well as and of the tract.

Underlined words are explained — tap any of them.

Symptoms — what it feels like

·Hypogammaglobulinemia, recurrent opportunistic ,

Causes — why it happens

·Uncertain; at least 30% have an identified heterogeneous gene and/or inheritance of

How it's found

·Exclusion of other possible causes of hypogammaglobulinemia

Treatment

· replacement therapy, symptom management

Complications

· manifestations; increased risk of malignancies such as carcinomas, non-Hodgkin ; lymphocytic infiltration of ; nodular regenerative hyperplasia; enteropathy

Outlook

·Varies by type; recent studies suggest those with only recurrent have little or no reduced life expectancy post-, while those with disease-related have around 50% survival rate 33 years post-diagnosis

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Plain-language summary adapted from Wikipedia. Not medical advice.