Familial Mediterranean fever

Familial Mediterranean fever (FMF) is a hereditary inflammatory disorder. FMF is an autoinflammatory disease caused by mutations in the Mediterranean fever (MEFV) gene, which encodes a 781–amino acid protein called pyrin. Whilst all ethnic groups are susceptible to FMF, it usually occurs in people of Mediterranean origin –including Levantines, Sephardic Jews, Mizrahi Jews, Ashkenazi Jews, Assyrians, Armenians, Azerbaijanis, Druze, Kurds, Greeks, Turks and Italians.

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