Erythromelalgia
Erythromelalgia, or Mitchell's disease, is a rare pain disorder in which blood , usually in the lower or hands, are episodically blocked, then become hyperemic and inflamed. There is severe burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Secondary erythromelalgia can result from small fiber peripheral of any cause, polycythemia vera, essential thrombocythemia, hypercholesterolemia, mushroom or mercury poisoning, and some disorders. Primary erythromelalgia is caused by of the voltage-gated sodium channel α-subunit gene SCN9A.
Underlined words are explained — tap any of them.
Symptoms — what it feels like
- ·episodic blockage of blood , usually in the lower or hands, hyperemia, , severe burning pain (in the small fiber nerves) and skin redness.
Causes — why it happens
- ·small fiber , polycythemia vera, essential thrombocythemia, stress, insomnia, hypercholesterolemia, mushroom or mercury poisoning, disorders, of the voltage-gated sodium channel α-subunit gene