Dilated cardiomyopathy
(DCM) is a condition in which the heart becomes enlarged and cannot pump blood effectively. Symptoms vary from none to feeling tired, leg swelling, and shortness of breath. It may also result in chest pain or fainting. can include heart failure, heart valve disease, or an irregular heartbeat.
Underlined words are explained — tap any of them.
Symptoms — what it feels like
- ·Feeling tired, leg swelling, shortness of breath, chest pain, fainting
Causes — why it happens
- ·, alcohol, cocaine, certain toxins, of pregnancy, in many cases the cause remains unclear, certain
How it's found
- ·Supported by , chest X-ray, echocardiogram
Treatment
- ·Lifestyle changes, medications, implantable cardioverter defibrillator, resynchronization therapy (CRT), heart
Complications
- ·Heart failure, heart valve disease, irregular heartbeat
Outlook
- ·Five-year survival rate ~50%
Across the gene set (LMNA, , MYH7, TNNI3, TNNT2), 150 -'' are actually seen in South Asians () - many European-absent and still clinically 'uncertain'. For cardiomyopathy, that's a pool of computationally-damaging, India-relevant, clinically-unresolved variants no one has systematically characterised.
A study that would help: Take the South-Asian-observed, European-absent, ClinVar-uncertain in LMNA, , MYH7, TNNI3, TNNT2 and triage them for : functional assays or family segregation to move them from 'uncertain' to a real call. Each reclassified is a usable diagnostic result.