D2I2.
autoimmune

Uveitis

Uveitis is of the uvea, the pigmented layer of the eye between the inner and the outer fibrous layer composed of the sclera and . The uvea consists of the middle layer of pigmented structures of the eye and includes the iris, ciliary body, and choroid. Uveitis is described anatomically, by the part of the eye affected, as , intermediate, or , or panuveitic if all parts are involved. Anterior uveitis (iridocyclitis) is the most common, with the of uveitis overall affecting approximately 1:4500, most commonly those between the ages of 20 and 60. Symptoms include eye pain, eye redness, floaters, and blurred vision, and ophthalmic examination may show ciliary blood and the presence of cells in the anterior chamber. Uveitis may arise spontaneously, have a component, or be associated with an disease or . While the eye is a relatively protected environment, its mechanisms may be activated, resulting in inflammation and destruction associated with T-cell activation.

Underlined words are explained — tap any of them.

Symptoms — what it feels like

  • ·Eye pain, eye redness, photophobia, increased floaters, blurred vision, loss of vision, or (particularly in children)

Causes — why it happens

  • ·Behçet disease, Crohn's disease, Fuchs heterochromic iridocyclitis, Granulomatosis with polyangiitis, HLA-B27 related uveitis, Juvenile , Sarcoidosis, Spondyloarthritis, Sympathetic ophthalmia, Tubulointerstitial nephritis and uveitis , brucellosis, herpesviruses, leptospirosis, Lyme disease, presumed ocular histoplasmosis syndrome, syphilis, toxocariasis, toxoplasmic chorioretinitis, , Zika fever

Complications

  • ·Cataract, Glaucoma, Uveitic Macular edema, Band Keratopathy
Plain-language summary adapted from Wikipedia. Not medical advice.