Brugada syndrome
Brugada (BrS) is a disorder in which the electrical activity of the heart is abnormal due to . It increases the risk of abnormal heart rhythms and sudden death. Those affected may have episodes of syncope. The abnormal heart rhythms seen in those with Brugada syndrome often occur at rest, and may be triggered by a fever.
Underlined words are explained — tap any of them.
Symptoms — what it feels like
- ·Passing out, sudden death
Causes — why it happens
- ·, certain medication
How it's found
- · (ECG), testing
Treatment
- ·Watchful waiting, implantable (ICD)
The sections below are general education drawn from public guidelines (NHS, Mayo, CPIC, WHO, ICMR). They are not individually reviewed by a clinician and are not medical advice — always talk to a doctor about your own health.
When to see a doctor
See a doctor if you have unexplained fainting, night-time gasping or a racing heartbeat, or if a close relative died suddenly at a young age. Symptoms can appear during fever, rest, or sleep.
Call emergency services for fainting with an irregular heartbeat, or if someone collapses and does not respond. Because a high fever can trigger dangerous rhythms, treat fevers promptly and get medical advice.
General guidance, not a diagnosis. When in doubt, see a doctor.
Questions to ask your doctor
- ?Which tests confirm this, and do I need genetic testing?
- ?Should my parents, siblings, and children be screened?
- ?How should I manage fevers to stay safe?
- ?Are there medicines I should avoid?
- ?What should my family do in an emergency?
- ?Do I need ongoing heart-rhythm monitoring?
What to note before your visit
- ·any fainting or near-fainting and when it happened
- ·family history of sudden death, especially when young
- ·episodes linked to fever, rest, or sleep
- ·a list of all medicines you take
Test yourself
0/4 answered4 quick questions on Brugada syndrome. Tap an answer to check it.
Across the gene set (KCNH2, , SCN5A), 125 -'' are actually seen in South Asians () - many European-absent and still clinically 'uncertain'. For brugada , that's a pool of computationally-damaging, India-relevant, clinically-unresolved variants no one has systematically characterised.
A study that would help: Take the South-Asian-observed, European-absent, ClinVar-uncertain in KCNH2, , SCN5A and them for brugada : functional or family segregation to move them from 'uncertain' to a real call. Each is a usable diagnostic result.