Pemphigus vulgaris
Pemphigus vulgaris is a rare blistering skin disease and the most common form of pemphigus. Pemphigus was derived from the Greek word pemphix, meaning blister. It is classified as a type II hypersensitivity reaction in which are formed against desmosomes, components of the skin that function to keep certain layers of skin bound to each other. As desmosomes are attacked, the layers of skin separate, and the picture resembles a blister. These blisters are due to acantholysis, or the breaking apart of intercellular connections through an autoantibody-mediated response. Over time the condition inevitably progresses without treatment: increase in size and distribution throughout the body, behaving physiologically like a severe burn.
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