{
  "method": "analytical HWE mean/variance from 1000G allele freqs; captures allele-frequency mean-shift, not LD or effect-size heterogeneity",
  "misstrat_note": "Mis-stratification % = share of a population above the European top-10% 'high risk' cutoff. Europeans = 10% by definition; higher = systematically over-flagged by a Euro-calibrated threshold.",
  "scores": [
    {
      "pgs_id": "PGS000033",
      "name": "GRSIR",
      "trait": "Type 2 diabetes",
      "variants_used": 10,
      "populations": [
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": 0.144,
          "misstrat_pct": 10.5
        },
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": 0.201,
          "misstrat_pct": 9.0
        },
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": 0.302,
          "misstrat_pct": 13.1
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": 0.544,
          "misstrat_pct": 22.4
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": 0.587,
          "misstrat_pct": 22.6
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": 0.641,
          "misstrat_pct": 24.5
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": 0.674,
          "misstrat_pct": 26.0
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": 0.789,
          "misstrat_pct": 29.9
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": 0.796,
          "misstrat_pct": 30.6
        }
      ]
    },
    {
      "pgs_id": "PGS000010",
      "name": "GRS27",
      "trait": "Coronary heart disease",
      "variants_used": 27,
      "populations": [
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": -1.516,
          "misstrat_pct": 0.0
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": -0.726,
          "misstrat_pct": 0.7
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": -0.552,
          "misstrat_pct": 1.6
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": -0.543,
          "misstrat_pct": 1.5
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": -0.513,
          "misstrat_pct": 1.6
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": -0.505,
          "misstrat_pct": 1.6
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": -0.397,
          "misstrat_pct": 2.7
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": -0.102,
          "misstrat_pct": 9.4
        },
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": 0.116,
          "misstrat_pct": 8.0
        }
      ]
    },
    {
      "pgs_id": "PGS000061",
      "name": "GRS_LDL",
      "trait": "LDL cholesterol",
      "variants_used": 37,
      "populations": [
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": -0.206,
          "misstrat_pct": 2.7
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": -0.007,
          "misstrat_pct": 8.5
        },
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": 0.098,
          "misstrat_pct": 10.1
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": 0.176,
          "misstrat_pct": 11.3
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": 0.176,
          "misstrat_pct": 11.6
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": 0.21,
          "misstrat_pct": 12.2
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": 0.31,
          "misstrat_pct": 15.3
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": 0.395,
          "misstrat_pct": 16.4
        },
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": 1.154,
          "misstrat_pct": 44.8
        }
      ]
    },
    {
      "pgs_id": "PGS000047",
      "name": "BCPRS_ER-",
      "trait": "Breast cancer (ER-negative)",
      "variants_used": 49,
      "populations": [
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": 0.07,
          "misstrat_pct": 11.1
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": 0.17,
          "misstrat_pct": 12.7
        },
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": 0.175,
          "misstrat_pct": 11.8
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": 0.269,
          "misstrat_pct": 14.2
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": 0.273,
          "misstrat_pct": 15.0
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": 0.275,
          "misstrat_pct": 15.1
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": 0.312,
          "misstrat_pct": 16.0
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": 0.355,
          "misstrat_pct": 17.3
        },
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": 0.975,
          "misstrat_pct": 37.3
        }
      ]
    },
    {
      "pgs_id": "PGS000067",
      "name": "PCa_PHS",
      "trait": "Prostate cancer",
      "variants_used": 46,
      "populations": [
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": 0.14,
          "misstrat_pct": 12.9
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": 0.344,
          "misstrat_pct": 18.9
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": 0.376,
          "misstrat_pct": 20.2
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": 0.396,
          "misstrat_pct": 20.7
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": 0.45,
          "misstrat_pct": 22.4
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": 0.674,
          "misstrat_pct": 29.4
        },
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": 0.684,
          "misstrat_pct": 23.7
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": 0.748,
          "misstrat_pct": 32.0
        },
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": 1.817,
          "misstrat_pct": 68.5
        }
      ]
    },
    {
      "pgs_id": "PGS000350",
      "name": "GRS12_POAG",
      "trait": "Primary open-angle glaucoma",
      "variants_used": 12,
      "populations": [
        {
          "pop": "EUR",
          "label": "European",
          "shift_vs_eur_sd": 0.0,
          "misstrat_pct": 10.0
        },
        {
          "pop": "AMR",
          "label": "Admixed American",
          "shift_vs_eur_sd": 0.185,
          "misstrat_pct": 12.9
        },
        {
          "pop": "GIH",
          "label": "Gujarati",
          "shift_vs_eur_sd": 0.214,
          "misstrat_pct": 13.2
        },
        {
          "pop": "PJL",
          "label": "Punjabi (Lahore)",
          "shift_vs_eur_sd": 0.371,
          "misstrat_pct": 16.8
        },
        {
          "pop": "SAS",
          "label": "South Asian (all)",
          "shift_vs_eur_sd": 0.399,
          "misstrat_pct": 17.2
        },
        {
          "pop": "ITU",
          "label": "Telugu (India)",
          "shift_vs_eur_sd": 0.417,
          "misstrat_pct": 17.1
        },
        {
          "pop": "BEB",
          "label": "Bengali",
          "shift_vs_eur_sd": 0.476,
          "misstrat_pct": 19.3
        },
        {
          "pop": "STU",
          "label": "Sri Lankan Tamil",
          "shift_vs_eur_sd": 0.528,
          "misstrat_pct": 20.2
        },
        {
          "pop": "EAS",
          "label": "East Asian",
          "shift_vs_eur_sd": 0.557,
          "misstrat_pct": 19.3
        },
        {
          "pop": "AFR",
          "label": "African",
          "shift_vs_eur_sd": 1.288,
          "misstrat_pct": 50.3
        }
      ]
    }
  ]
}